Lindsay A. Holden, Ph.D., DABT

Senior Toxicologist/Regulatory Scientist

F: 202-557-3836

Overview

Lindsay A. Holden, Ph.D., DABT^®, is a Senior Toxicologist and Regulatory Scientist with Bergeson & Campbell, P.C. (B&C^®). Dr. Holden has extensive experience in molecular mechanisms of exposure across a wide range of chemicals and materials. As a toxicologist with the U.S. Army Public Health Center, she conducted numerous human health and environmental hazard and risk assessments in occupational, hazardous waste, and military base settings. Dr. Holden also led teams of researchers conducting basic and early-stage medical research and development as Neuroscience Department Chief at the U.S. Army Medical Research Institute of Chemical Defense. Dr. Holden is a powerful and experienced advocate for clients engaged with the U.S. Environmental Protection Agency (EPA) on Toxic Substances Control Act (TSCA) risk assessments and risk management rules, and is well-suited to assist clients in preparing, analyzing, and interpreting environmental, toxicity, and public health data to support regulatory compliance and sustained commercial success.

Dr. Holden has a proven track record of analyzing and anticipating regulatory impacts on project costs, schedules, and performance outcomes and developing proactive plans to reduce those impacts throughout the supply chain. She has served as the project manager or senior scientist on public health and environmental compliance efforts under statutes including TSCA, the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), the Resource Conservation and Recovery Act (RCRA), the Clean Water Act (CWA), and the Clean Air Act (CAA). Dr. Holden is skilled in data collection and interpretation and has over a decade of experience designing and conducting studies using in silico, in vitro, and in vivo models following Good Laboratory Practices (GLP) and Organisation for Economic Co-operation and Development (OECD) guidelines.

Professional and Community Involvement

Member of the Society of Toxicology (SOT)
Molecular and Systems Biology Specialty Section Treasurer, SOT, 2019 – 2023
Member of the American Association for the Advancement of Science (AAAS)
Early Career Scientist Steering Committee, Genetics Society of America, 2018 – 2020
Peer reviewer, International Journal of Toxicology, 2018 – present
Peer reviewer, Drug and Chemical Toxicology, 2017 – present
Peer reviewer, Journal of Occupational and Environmental Medicine, 2025 – present

Articles and Writings

Holden, L. A., East, A. G., Narizzano, A. M., & Quinn Jr, M. J. (2023). Toxicology assessment for six per‐and polyfluoroalkyl (PFAS)‐free aqueous film forming foam (AFFF) products. Integrated Environmental Assessment and Management, 19(6), 1609-1618.
East, A. G., Narizzano, A. M., Holden, L. A., Bazar, M. A., Bohannon, M. E., Pervitsky, D., Adams, V. H., Reinke, E. N., Quinn Jr, M. J. (2023). Comparative toxicity of seven aqueous film‐forming foam to in vitro systems and Mus. Environmental Toxicology and Chemistry, 42(11), 2364-2374.
East, A. G., Narizzano, A. M., Holden, L. A., & Quinn, M. J. (2022). Ecotoxicity of new film forming foams: Acute and subacute toxicity tests in Mus musculus. U.S. Army Public Health Center.
Holden, L. A., East, A. G., & Narizzano, A. M. (2022). Toxicology assessment for Strategic Environmental Research and Development Program: PFAS-Free AFFFs (Toxicology Report No. S.0079790 and S.0082073). U.S. Army Public Health Center.

Adams, V. H., East, A. G., Holden, L. A., & Reinke, E. N. (2022). Toxicity assessment of the novel energetic 1-methyl-2,4,5-trinitroimidazole (MTNI) April 2020–April 2022 (Toxicity Assessment No. S.005223.2-19).
U.S. Army Public Health Center. (2020). Restricted distribution.
Williams, M. A., Holden, L. A., Quinn, M. J., & Reddy, G. (2020). WTA No. HEF-0420190-007 Wildlife toxicity assessment for diethyl phthalate. U.S. Army Public Health Center.
Williams, M. A., Holden, L. A., Quinn, M. J., & Reddy, G. (2020). WTA No. HEF-0420190-003 Wildlife toxicity assessment for dimethyl phthalate (DMP). U.S. Army Public Health Center.
Eck, W. S., & Holden, L. A. (2020). Toxicology assessment for U.S. Department of Defense Strategic Environmental Research and Development Program Project WP-2400: Environmentally sustainable liquid gas generator formulations (Toxicity Assessment No. S.0026122-15). U.S. Army Public Health Center.
Eck, W. S., & Holden, L. A. (2019). Toxicology assessment for EQT Project TMR 14-02: Cr(VI)-free conversion coatings (Toxicology Report S.0052729-14). U.S. Army Public Health Center.
Holden, L. A., & Adams, V. A. (2018). Ames mutagenicity test of the novel energetics: 1,4-dimethyl-1,2,4- triazolium nitrate (DTN), 1,4-di-H-3,5-diamino-1,2,4-triazolium nitrate (DATN), 3-amino-1,2,4-triazolium nitrate (ATN), 1-methyl-4-H-5-amino-1,2,3,4-tetrazolium nitrate (MATN), and 2,4,6-triamino-1-H-pyridinium nitrate (TAPyNO3) (Toxicology Study No. S.0040699a-16, Protocol No. 2758-70-IV16-03-01 A, B, C, D, E).
Holden, L. A., Wilson, C., Heineman, Z., Dobrinski, K. P., & Brown, K. H. (2019). An interrogation of conserved copy number variation across genetically distinct strains of zebrafish. Zebrafish, 16(1), 29-36.
Holden, L. A., Arumilli, M., Hundi, S., Hytonen, M. K., Salojarvi, J., Brown, K. H., & Lohi, H. (2018). Assembly and analysis of unmapped genome sequence reads reveal novel sequence and variation in dogs. Scientific Reports, 8(1), 10862.
Holden, L. A., & Brown, K. H. (2018). Baseline mRNA expression differs widely between common laboratory strains of zebrafish. Scientific Reports, 8(1), 4780.
Hammarlund, E., Thomas, A., Amanna, I. J., Holden, L. A., Slayden, O. D., Park, B., Gao, L., & Slifka, M. K. (2017). Plasma cell survival in the absence of B cell memory. Nature Communications, 8(1), 1781.
Jensen, J. T., Hanna, C., Yao, S., Micks, E., Edelman, A., Holden, L., & Slayden, O. D. (2014). Blockade of tubal patency following transcervical administration of polidocanol foam: Initial studies in rhesus macaques. Contraception, 89(6), 540-549.
Almeida-Francia, C. C. D., Keator, C. S., Mah, K., Holden, L., Hergert, C., & Slayden, O. D. (2012). Localization and hormonal regulation of endometrial matrix metalloproteinase-26 in the rhesus macaque. Human Reproduction, 1 27(6), 1723-1734.
Keator, C. S., Mah, K., Ohm, L., & Slayden, O. D. (2011). Estrogen and progesterone regulate expression of the endothelins in the rhesus macaque endometrium. Human Reproduction, 26(7), 1715-1728. (Maiden name is Ohm.)

B&C, Acta, and BCCM provide a full range of global support for the commercialisation of chemicals, biocides, and products of industrial biotechnology, nanotechnology, and synthetic biology.

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Lindsay A. Holden, Ph.D., DABT

Overview

Professional and Community Involvement

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B&C, Acta, and BCCM provide a full range of global support for the commercialisation of chemicals, biocides, and products of industrial biotechnology, nanotechnology, and synthetic biology.

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