Nano and Other Emerging Chemical Technologies Blog

On May 20, 2025, the National Academies of Sciences, Engineering, and Medicine (NASEM) announced the release of a report entitled Quadrennial Review of the National Nanotechnology Initiative (2025): Securing U.S. Global Leadership Through Renewed and Expanded Infrastructure. Requested by Congress as part of the 21st Century Nanotechnology Research and Development Act, the report focuses on the infrastructure of the National Nanotechnology Initiative (NNI). The Committee on the Quadrennial Review...

On June 19 to June 20, 2025, the European Union (EU) Horizon Europe projects ACCORDs, iCare, MACRAMÉ, and nanoPASS are hosting a joint summit to address the needs of industry and regulators in assessing the safety and sustainability of advanced materials. The summit will feature discussions, latest method developments, and direct engagement with regulators, scientists, and industry professionals. Key sessions will focus on regulatory challenges, scientific developments, and pathways towards...

On April 8, 2025, the European Union (EU) Observatory for Nanomaterials (EUON) published a Nanopinion entitled “A Qualification System to Accelerate Development and Regulatory Implementation of New Approach Methodologies (NAMs)” by Andrea Haase, Ph.D., German Federal Institute for Risk Assessment (BfR), Shirin M. Usmani, Ph.D., BfR, Irene Cattaneo, European Food Safety Authority (EFSA), Maria Chiara Astuto, EFSA, and Francesco Cubadda, Ph.D., National Institute of Health (ISS). The authors...

On April 3, 2024, the European Commission’s (EC) Scientific Committee on Consumer Safety (SCCS) began a public consultation on its preliminary opinion on the safety of hydroxyapatite (nano) in oral products. The EC asked SCCS if it considers hydroxyapatite (nano) safe when used in toothpaste up to a maximum concentration of 29.5 percent and in mouthwash up to a maximum concentration of ten percent according to the specifications as reported in the submission, taking into account reasonably...

On February 6, 2025, the European Union (EU) Advocate General (EU AG) recommended that the European Court of Justice (ECJ) overturn the 2022 decision of the General Court annulling the 2019 harmonized classification and labeling of titanium dioxide as a carcinogenic substance by inhalation in certain powder forms. As reported in our December 6, 2022, memorandum, the court annulled the European Commission’s (EC) decision to classify titanium dioxide as a suspected human carcinogen. The French...

The Organisation for Economic Co-operation and Development (OECD) has published the Developments in Delegations on the Safety of Manufactured Nanomaterials and Advanced Materials between July 2023 and June 2024 -- Tour de Table (Tour de Table). Below are highlights on international developments from the Tour de Table: Canada continues with the risk assessments of zinc oxide and titanium dioxide at the nanoscale that are in commerce in Canada, to evaluate their potential for environmental and...

The Organisation for Economic Co-operation and Development (OECD) has published the Developments in Delegations on the Safety of Manufactured Nanomaterials and Advanced Materials between July 2023 and June 2024 -- Tour de Table (Tour de Table). The Tour de Table lists U.S. developments on the human health and environmental safety of nanomaterials. Risk assessment decisions, including the type of nanomaterials assessed, testing recommended, and outcomes of the assessment include: The U.S....

On December 19, 2024, the National Nanotechnology Coordination Office (NNCO) released The National Nanotechnology Initiative Supplement to the President’s 2025 Budget, which also serves as the annual report for the National Nanotechnology Initiative (NNI). According to the report, President Biden’s fiscal year (FY) 2025 budget requests over $2.2 billion for NNI, with cumulative funding totaling over $45 billion since the inception of NNI in 2001 when Congress approved increased funding for...

On December 18, 2024, the National Nanotechnology Initiative (NNI) announced the availability of the National Nanotechnology Initiative Environmental, Health, and Safety Research Strategy: 2024 Update. Prepared by the Nanotechnology Environmental and Health Implications (NEHI) Working Group within the Nanoscale Science, Engineering, and Technology (NSET) Subcommittee of the National Science and Technology Council, the 2024 update builds on the initial 2011 strategy, laying out a comprehensive,...

The European Union (EU) Observatory for Nanomaterials (EUON) announced on December 4, 2024, the availability of the European Chemical Agency’s (ECHA) Second interim evaluation of the European Union Observatory for Nanomaterials (EUON). Prepared by WSP acting as a third-party evaluator, the interim evaluation assesses EUON against six criteria: effectiveness; efficiency (including economy and proportionality); relevance; coherence; EU-added value; and utility. WSP’s recommendations include:...

On December 12, 2024, the U.S. Environmental Protection Agency (EPA) issued several final significant new use rules (SNUR) for certain chemical substances that were the subject of premanufacture notices (PMN) and are also subject to an Order issued by EPA pursuant to the Toxic Substances Control Act (TSCA). 89 Fed. Reg. 100361. Two of the SNURs are for substances identified generically as multi-walled carbon nanotubes (PMN P-21-216 and PMN P-21-217). The SNURs require persons who intend to...

The European Union (EU) Observatory for Nanomaterials (EUON) announced on November 12, 2024, that it published a new study evaluating nanomaterials applications in biocidal, plant protection, and fertilizing products used in agriculture. The study, “Collection and review of information on nanomaterial-based and nano-enabled plant protection products, biocidal products and fertilising products,” addresses knowledge gaps on applications, exposure, and hazards of nanomaterials and...

The European Commission’s (EC) Scientific Committee on Consumer Safety (SCCS) published its final opinion on a new coating for titanium dioxide on October 25, 2024. According to the abstract, SCCS concluded that “there are a number of uncertainties and data gaps that do not allow a conclusion on the safety of titanium dioxide (nano) coated with a combination of w/w 6% Aluminium Hydroxide, 14% Sodium Myristoyl Sarcosinate and 10% Dimethicone (Eclipse 70) -- either on the basis of a similarity...

The National Nanotechnology Coordination Office (NNCO) is organizing a series of National Nanotechnology Initiative (NNI) webinars on nanometrology, metrological challenges, and recent advances in three topical areas: food, agriculture, and the environment; nanoscale medical and pharmaceutical products; and nanoparticles in electronics. Registration is open for the sixth webinar in the series, “Nanometrology for Continuous and Automated Manufacturing.” The November 1, 2024, webinar will...

On October 10, 2024, the European Union (EU) Observatory for Nanomaterials (EUON) announced that, in collaboration with NovaMechanics, it is conducting a survey to gather insights on analytical methods for identifying, characterizing, and quantifying carbon-based nanomaterials in various matrices. According to EUON, the initiative “aims to assess the current situation about analytical methods for these types of nanomaterials, whether advanced or more classical nanomaterials.” Responses will...

The European Union (EU) Observatory for Nanomaterials (EUON) announced on September 26, 2024, that the European Food Safety Authority (EFSA) has published the following reports under its NAMs4NANO Project: “Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges” is a review article on the currently available New Approach Methodologies (NAM) that are potentially useful for risk assessment of nanoparticles in...

On October 5, 2024, the Minister of the Environment announced in the Canada Gazette publication of a proposed plan of priorities for the assessment of chemical substances. Under the 2023 amendments to the Canadian Environmental Protection Act, 1999 (CEPA), the Minister of the Environment and the Minister of Health are required to “develop, consult on and publish a plan with timelines” by June 2025. The proposed list of prioritized substances for assessment and the rationales for priorities...

On September 25, 2024, the National Institute for Occupational Safety and Health (NIOSH) posted a NIOSH Science Blog item entitled “Celebrating 20 Years of the Nanotechnology Research Center: Measuring the Small Things,” the final installment of the blog series commemorating the 20th anniversary of the Nanotechnology Research Center (NTRC). According to the item, when NTRC was created in 2004, one of its biggest challenges was understanding exactly what to measure and how to measure it....

The National Institute for Occupational Safety and Health (NIOSH) posted a blog item on September 10, 2024, entitled “NTRC Marks 20 Years of Studying Nanotoxicology: Highlights from the Toxicology and Internal Dose Team” that reviews the Nanotechnology Research Center’s (NTRC) achievements in the field of nanotechnology. The blog item highlights where NTRC started, where it is now, NTRC’s partnerships, and its work modeling workplace exposure to assess toxicity. According to the blog...

The National Nanotechnology Coordination Office (NNCO) is organizing a series of National Nanotechnology Initiative (NNI) webinars on nanometrology, metrological challenges, and recent advances in three topical areas: food, agriculture, and the environment; nanoscale medical and pharmaceutical products; and nanoparticles in electronics. Registration is open for the fifth webinar in the series, “Nanometrology for Continuous and Automated Manufacturing.” The October 4, 2024, webinar will...

As part of its quadrennial review of the National Nanotechnology Initiative (NNI), the National Academies of Sciences, Engineering, and Medicine (NASEM) will hold a virtual town hall on September 5, 2024, for stakeholders to share their thoughts on the future of nanotechnology in the United States. The overall objective of NASEM’s review is to identify opportunities and barriers to broadening access to nanotechnology research and development (R&D) infrastructure in the United States. As...

On August 20, 2024, the U.S. Environmental Protection Agency (EPA) proposed significant new use rules (SNUR) ) under the Toxic Substances Control Act (TSCA) for chemical substances, including graphene nanoplatelets (generic), that were the subject of premanufacture notices (PMN) and a Microbial Commercial Activity Notice (MCAN) and are also subject to a TSCA Order. 89 Fed. Reg. 67368. The SNURs would require persons who intend to manufacture (defined by statute to include import) or process any...

The U.S. Environmental Protection Agency (EPA) is seeking applications for research to develop and demonstrate nanosensor technology with the potential to detect, monitor, and degrade per- and polyfluoroalkyl substances (PFAS) in groundwater or surface water that may be used as drinking water sources. EPA states that advances in nanoscience and nanotechnology have the potential to address the challenges of detection and treatment of PFAS-contaminated waters. Because nanomaterials are smaller in...

The National Institute for Occupational Safety and Health (NIOSH) posted a blog item on August 1, 2024, entitled “When Nanoparticles Blow Up -- Explosion Hazards of Nanoparticles.” According to the blog item, little is known about the potential explosivity of any material when subdivided down to the nanoscale, prompting the NIOSH Nanotechnology Research Center (NTRC) to study the explosivity of several classes of nanoparticles: Nanocarbons: NIOSH screened single-walled carbon nanotubes,...

The 2024 National Institute for Occupational Safety and Health (NIOSH) Nanotechnology Research Center (NTRC) Nanotechnology Health and Safety Summit will be held October 9-10, 2024. During the conference, industry, academic, and government experts will share the latest advancements in occupational exposure to nanotechnology and advanced materials. The conference will also address critical safety and health challenges and offer valuable insights and foresights on a range of cutting-edge topics,...

The European Commission (EC) launched a call on July 5, 2024, for applications for members of the new Technology Council for Advanced Materials. According to the Directorate General (DG) for Internal Market, Industry, Entrepreneurship and SMEs, “this high-level group will coordinate efforts to meet future needs for advanced materials in Europe, and is key to building a single advanced materials ecosystem.” The EC’s February 2024 Communication on Advanced Materials for Industrial Leadership...

On July 1, 2024, the National Institute for Occupational Safety and Health (NIOSH) posted a NIOSH Science Blog item entitled “Celebrating 20 Years of the Nanotechnology Research Center: Highlights from Engineering Controls and Personal Protective Equipment,” part of a series commemorating the 20th anniversary of the Nanotechnology Research Center (NTRC). The item notes that NIOSH researchers “have conducted laboratory and field research to develop and implement science-based national...

The National Nanotechnology Initiative (NNI) and the National Nanotechnology Coordination Office (NNCO) are convening a July 24, 2024, workshop, “Responsible Development, Social Science, and the National Nanotechnology Initiative: A Workshop to Explore Past and Future Intersections.” According to NNI, the workshop will bring together federal experts in nanotechnology with social scientists with expertise on specific tools and frameworks relevant to the responsible development of emerging...

The European Chemicals Agency (ECHA) is evaluating the function of the European Union (EU) Observatory for Nanomaterials (EUON). As part of its evaluation, ECHA is conducting a survey to collect responses from EUON website visitors and stakeholders. The survey includes questions concerning evaluation criteria such as use, effectiveness, coherence, EU-added value, and utility. The survey notes that under an ongoing legislative proposal, the European Commission (EC) foresees setting up a common...

On June 12, 2024, the European Chemicals Agency (ECHA) announced that it updated its report on key areas of regulatory challenge, providing more detailed information on areas where scientific research is needed to protect human health and the environment from hazardous chemicals. The report addresses micro- and nano-size materials, stating: Why further research is needed: Critical test methods to address the human and environmental hazard and risk assessment of nanomaterials are still missing....

The National Nanotechnology Coordination Office (NNCO), on behalf of the Nanoscale Science, Engineering, and Technology (NSET) Subcommittee of the Committee on Technology, National Science and Technology Council (NSTC), requested comments on June 13, 2024, on the “National Nanotechnology Initiative Environmental, Health, and Safety Research Strategy: 2024 Update” (2024 Update). 89 Fed. Reg. 50390. NNCO states that federal agencies participating in NSET’s Nanotechnology Environmental and...

The National Nanotechnology Initiative (NNI) will hold a webinar on June 27, 2024, on “What’s Next in NanoEHS: Risk Assessment and Risk Management.” During the webinar, rising nanotechnology environmental, health, and safety (nanoEHS) experts Nathan Drew, National Institute for Occupational Safety and Health (NIOSH), and Yueyang “Brian” Zhang, Vireo Advisors, LLC, will share their perspectives on the new tools, approaches, and models that are being developed to assess and manage...

On June 11, 2024, the U.S. Environmental Protection Agency (EPA) published proposed significant new use rules (SNUR) for certain chemical substances that were the subject of premanufacture notices (PMN) and are also subject to a TSCA Order, including multi-walled carbon nanotubes (generic) (P-21-216 and P-21-217). 89 Fed. Reg. 49121. The SNURs would require persons who intend to manufacture (including import) or process any of these chemical substances for an activity that is proposed as a...

The National Institute for Occupational Safety and Health (NIOSH) continues to celebrate the 20th anniversary of its Nanotechnology Research Center (NTRC). NIOSH highlights NTRC activities in the risk assessment of engineered nanomaterials in a June 3, 2024, NIOSH Science blog item entitled “NIOSH Risk Assessment of Engineered Nanomaterials.” The item notes that NTRC risk assessments were used in developing NIOSH recommended exposure limits (REL) for three different classes of nanomaterials...

The European Commission’s (EC) Scientific Committee on Consumer Safety (SCCS) began a public consultation on May 27, 2024, on its preliminary opinion on a new coating for titanium dioxide (nano form). According to the preliminary opinion, SCCS concluded that: Considering all the provided information, SCCS is of the view that there are a number of uncertainties and data gaps that do not allow a conclusion on the safety of titanium dioxide (nano) coated with a combination of six percent by...

On May 23, 2024, the European Commission’s (EC) Scientific Committee on Consumer Safety (SCCS) published a document entitled “Scientific Advice on Titanium dioxide (TiO2).” The document includes the following questions from the EC and SCCS’s conclusions: Q:In light of the European Food Safety Authority’s (EFSA) opinion on genotoxicity concerns for E171, does SCCS consider titanium dioxide safe in oral cosmetic products? A:From the provided information, SCCS notes that the titanium...

On April 29, 2024, the German Environment Agency (UBA) posted an item entitled “ZnO nanoforms - REACH substance evaluation: environmental aspects.” The Federal Office for Chemicals, the Federal Institute for Risk Assessment (BfR), and UBA have been conducting a Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) substance evaluation on the registered nanoforms of zinc oxide since 2017. According to the item, based on the studies submitted by the registrants, UBA has...

The National Institute for Occupational Safety and Health (NIOSH) posted a NIOSH Science Blog item on May 2, 2024, entitled “The Nanotechnology Research Center Carbon Nanotube Registry.” The NIOSH Nanotechnology Research Center (NTRC) maintains a Carbon Nanotube Registry, a roster of U.S. workers employed in various carbon nanotube industries. The item states that NIOSH developed the registry to help researchers better understand the average level and range of exposures in U.S. workplaces...

The European Union (EU) Observatory for Nanomaterials (EUON) invites proposals for upcoming studies aimed at addressing knowledge gaps for nanomaterials within the EU market, such as: Questions related to the health and safety aspects of nanomaterials, including hazard and risk assessment; Specific issues surrounding the uses, associated risks, and benefits of nanomaterials; or Information about markets of nanomaterials. EUON notes that studies are based on desk research and surveys and should...

The U.S. Department of Agriculture’s (USDA) Agricultural Research Service announced on April 9, 2024, that ARS researchers published a study revealing the ability of cotton gin waste to synthesize and generate silver nanoparticles in the presence of silver ions. ARS states that cotton gin waste, also known as cotton gin trash, “is a byproduct of the cotton ginning process and occurs when the cotton fibers are separated from the seed boll.” Using a simple heat treatment of cotton gin waste...

The U.S. Environmental Protection Agency (EPA) posted a research update on April 2, 2024, entitled “Advancing Environmental Safety: Celebrating 20 years of Nanotechnology Research at EPA.” The item states that EPA collaborates across federal and state governments, industry, and the international community on nano-related research. In addition to its in-house nanotechnology research, EPA supports nano-related research through external grant programs such as the Science to Achieve Results...

The National Institute for Occupational Safety and Health (NIOSH) Nanotechnology Research Center’s (NTRC) Field Studies Team (the Team) evaluates advanced materials and processes in workplaces ranging from large manufacturers, research and development labs, and government facilities, to schools, libraries, and other non-industrial settings. An April 1, 2024, NIOSH Science Blog item entitled “Celebrating 20 Years of Research: Highlights From NIOSH’s Nanotechnology Research Center’s Field...

On March 15, 2024, the European Commission (EC) published in the Official Journal of the European Union an amendment to the Cosmetics Regulation. The following nanomaterials have been added to Annex II (substances prohibited in cosmetic products). From February 1, 2025, cosmetic products containing these substances shall not be placed on the European Union (EU) market. From November 1, 2025, cosmetic products containing these substances shall not be made available on the EU market:...

The Organisation for Economic Co-operation and Development (OECD) published the report of the first Working Party on Manufactured Nanomaterials (WPMN) workshop on NanoCarriers. The report states that NanoCarriers (nano-scaled structures loaded with an active substance) “promise benefits for various fields of applications but they also present great diversity in terms of chemical composition, structural features, and applications.” The June 14-15, 2023, workshop included governmental...

The National Nanotechnology Coordination Office (NNCO) is organizing a series of National Nanotechnology Initiative (NNI) webinars on nanometrology, metrological challenges, and recent advances in three topical areas: food, agriculture, and environment; nanoscale medical and pharmaceutical products; and nanoparticles in electronics. Registration is open for the fourth webinar in the series, Metrology of Nanoparticles in Electronics, which will be held April 5, 2024, at 12:00 p.m. (EDT). The...

On March 5, 2024, the National Nanotechnology Initiative (NNI) held a symposium entitled “Enabling the Nanotechnology Revolution: Celebrating the 20th Anniversary of the 21st Century Nanotechnology Research and Development Act.” The White House Office of Science and Technology Policy (OSTP) posted a readout of the symposium on March 6, 2024. According to OSTP, during the symposium, “leaders from academia, government, and industry spoke about U.S. success in nanotechnology and future...

On March 5, 2024, the National Nanotechnology Initiative (NNI) published its supplement to the President’s 2024 budget request. NNI states that the President’s 2024 budget requests an “all-time record” of $2.16 billion for it, with a sustained investment in foundational research that will fuel new discoveries and increase investments in application-driven research and development (R&D) to advance technologies of the future and address national priorities. The President’s 2024...

In a March 4, 2024, blog item entitled “Sweating the Small Stuff: 20 years of NIOSH Research on Engineering Controls for Nanotechnology,” the National Institute for Occupational Safety and Health (NIOSH) highlighted the control approaches that it has recommended, “based on extensive research on the pharmaceutical, coatings, and cosmetic industries”: General Safe Practices for Working with Engineered Nanomaterials in Research Laboratories (2012): Provides approaches to working with...

The February 2024 issue of Nature Nanotechnology includes an article entitled “How nanoparticles are counted in global regulatory nanomaterial definitions.” Authored by Kirsten Rasmussen, Juan Riego Sintes, and Hubert Rauscher, European Commission (EC) Joint Research Center (JRC), the article examines differences between the definitions in various jurisdictions and how to achieve a global definition. The jurisdictions reviewed include Organization for Economic Cooperation and Development...

The National Nanotechnology Coordination Office (NNCO) is organizing a series of National Nanotechnology Initiative (NNI) webinars on nanometrology, metrological challenges, and recent advances in three topical areas: food, agriculture, and environment; nanoscale medical and pharmaceutical products; and electronics. Registration is open for the third webinar in the series, Nanoscale Medical and Pharmaceutical Products, which will be held March 1, 2024, at 12:00 p.m. (EST). The webinar will...