Nano and Other Emerging Chemical Technologies Blog

As part of the activities of the European Union (EU) Observatory for Nanomaterials (EUON), the European Chemicals Agency (ECHA) has commissioned a study on “Nanomaterials used as or integrated into flame retardants.” According to EUON, the study aims to collect and review scientific and market information on nanomaterials used as or integrated into flame retardants in consumer and professional products. EUON states that the objective is to assess their performance, potential health and...

On December 12, 2025, the Organisation for Economic Co-operation and Development (OECD) published a report entitled Safe and sustainable by design tools, integrative systems and platforms for nanomaterials and nano-enabled products. According to OECD, the report advances the implementation of safe and sustainable by design (SSbD) for nanomaterials by compiling and reviewing tools, integrative systems, and platforms that support design, risk assessment, and sustainability considerations. The...

On December 12, 2025, the Organisation for Economic Co-operation and Development published a report entitled The Identification of Exposure Metrics for Use in Evaluation of Inhalation Exposure to Nano-Objects and their Aggregates and Agglomerates (NOAA) in the Workplace. The report presents a comprehensive overview, informed by a literature review, on methods for assessing and measuring inhalation exposure to nano-objects and their aggregates and agglomerates (NOAA) in workplace environments....

On December 1, 2025, the European Union (EU) Observatory for Nanomaterials (EUON) announced the availability of a report analyzing the applications of nano-enabled textiles and their presence on the EU and global markets. The report, Information on Nano-Enabled Textiles, addresses the growing integration of nanotechnology in the textile industry, which has introduced advanced functionalities such as antimicrobial properties, enhanced durability, water repellence and ultraviolet (UV) protection....

The United Kingdom (UK) NanoSafety Group (UKNSG) has published the third edition of its guidance entitled “Working Safely with Nanomaterials in Research & Development.” The guidance is intended to provide help and support to research laboratories in industry, research, and training organizations and academia on how to comply with their occupational health and safety legal obligations. The guidance also includes additional information to help improve health and safety systems when working...

The Scientific Committee on Consumer Safety (SCCS) announced on October 30, 2025, that the European Commission (EC) requested a scientific opinion on the safety of hydrated silica (nano), pyrogenic silica (nano), silica silylate (nano), and silica dimethyl silylate (nano). The request states that given the continued and widespread use of these silica materials in cosmetic products, and in view of the previous inconclusive assessments by SCCS and the new submission of safety data by industry, the...

The Organisation for Economic Co-operation and Development (OECD) has published a draft guidance document on in vitro testing for intestinal fate of orally ingested nanomaterials. According to OECD, the new guidance document “would establish a conceptual framework and procedures for determining intestinal fate of orally ingested nanomaterials using an integrated in vitro approach simulating the human [gastrointestinal tract] environment.” The primary objective of the draft guidance document...

On October 21, 2025, the European Commission (EC) announced that it has called for evidence and begun a public consultation on the upcoming Advanced Materials Act, “a key initiative under the Competitiveness Compass.” According to the EC, the Act will establish a strategic framework for the development, deployment, and production of advanced materials. The EC states that advanced materials “are intentionally designed and engineered materials with innovative properties and functionalities,...

The European Union (EU) Observatory for Nanomaterials (EUON) has contracted the Nanotechnology Industries Association (NIA) and Yordas Group to undertake a study on the assessment of health and environmental hazards and risks of surface-treated nanomaterials. The aim of the study is to review and collect scientific information and data on how surface treatment can affect the properties of nanomaterials and potentially have an impact on their fate and potential risks. The study includes a market...

The Organisation for Economic Co-operation and Development (OECD) has published a September 2025 document entitled Guidance Document on Assessing the Apparent Accumulation Potential of Nanomaterials. The document is intended to provide specific advice on how to conduct bioaccumulation tests in fish with nanomaterials following Test Guideline (TG) 305 (OECD 2012), once it has been decided that such a fish test is needed. The purpose is to offer guidance on the critical points indicated in the...

The Scientific Committee on Consumer Safety (SCCS) announced on September 18, 2025, that the European Commission (EC) has requested a scientific opinion on the safety of titanium dioxide (nano and non-nano) in cosmetic products. As reported in our May 24, 2024, blog item, on May 23, 2024, SCCS published a document entitled “Scientific Advice on Titanium dioxide (TiO2).” The document noted that the available evidence was not sufficient to exclude the genotoxicity potential of almost all of...

The Particles Platform, an informal alliance of European Union (EU) industry associations representing manufacturers of materials in the form of particles, including poorly soluble low toxicity particles (PSLT), will hold a workshop on October 2, 2025. The workshop intends to advance regulatory science on particles through new evidence on inhalation toxicity. It will explore the regulatory landscape for particles and provide attendees an opportunity to: Access the latest research on particle...

The International Organization for Standardization (ISO) recently published two standards for graphene-related two-dimensional (2D) materials: ISO/TS 9651:2025, Nanotechnologies -- Classification framework for graphene‐related 2D materials: The document specifies the characteristics and their respective measurement methods of graphene-related 2D materials in sheet and particle forms for commercial applications with the aim of classification of the materials. The classification framework...

On July 23, 2025, Environment and Climate Change Canada (ECCC) announced the release of the Plan of Priorities, a multi-year plan that outlines upcoming priorities for the assessment of chemical substances. The Plan includes a list of more than 30 substances and substance groups prioritized for assessment and includes new or expanded activities to help assess, control, and manage risks posed by substances. ECCC states that in selecting and prioritizing these substances, considerations included:...

On August 1, 2025, the European Court of Justice (ECJ) issued a judgment upholding the 2022 decision of the General Court annulling the 2019 harmonized classification and labeling of titanium dioxide as a carcinogenic substance by inhalation in certain powder forms. As reported in our December 6, 2022, memorandum, the court annulled the European Commission’s (EC) decision to classify titanium dioxide as a suspected human carcinogen. The French government and the EC appealed the decision,...

On July 29, 2025, the U.S. Environmental Protection Agency (EPA) issued final significant use rules (SNUR) for certain chemical substances, including graphene nanoplatelets (generic), that were the subject of premanufacture notices (PMN) and a Microbial Commercial Activity Notice (MCAN) and are also subject to an Order issued by EPA pursuant to the Toxic Substances Control Act (TSCA). 90 Fed. Reg. 35624. The SNURs require persons who intend to manufacture (including import) or process any of the...

On July 1, 2025, the European Commission’s (EC) Scientific Committee on Consumer Safety (SCCS) issued a final opinion on hydroxyapatite (nano) in oral products. The EC asked SCCS if it considers hydroxyapatite (nano) safe when used in toothpaste up to a maximum concentration of 29.5 percent and in mouthwash up to a maximum concentration of ten percent according to the specifications as reported in the submission, taking into account reasonably foreseeable exposure conditions. According to the...

The National Academies of Sciences, Engineering, and Medicine (NASEM) will hold a webinar on July 17, 2025, on “Nanotechnology R&D Infrastructure: Then and Now.” NASEM states that in the two decades since the authorization of the National Nanotechnology Initiative (NNI), the United States has become a global leader in the field with world-class research and development (R&D) infrastructure, but asks what new capabilities are needed to support emerging technologies. The webinar will...

On June 30, 2025, the Organisation for Economic Co-operation and Development (OECD) published a report entitled 2D Titanium Carbide MXenes: Case Study Report on Advanced Materials. Within OECD’s Working Party on Manufactured Nanomaterials (WPMN), the Steering Group on Advanced Materials conducted a case study on the potential issues of 2D titanium carbide MXenes. The report describes MXenes as “a group of [two-dimensional (2D)] advanced materials composed of transition metal carbides or...

On June 11, 2025, the Nanotechnology Industries Association (NIA) published a position paper entitled Bridging the Governance Gap: Divergent EU Approaches to Nano and Advanced Materials that highlights industry challenges with divergent approaches to nano and advanced materials in the European Union (EU). NIA notes that the EU “is at a critical juncture in the approach that it takes towards nano and other advanced materials.” According to NIA, with the European Commission’s (EC)...

On May 20, 2025, the National Academies of Sciences, Engineering, and Medicine (NASEM) announced the release of a report entitled Quadrennial Review of the National Nanotechnology Initiative (2025): Securing U.S. Global Leadership Through Renewed and Expanded Infrastructure. Requested by Congress as part of the 21st Century Nanotechnology Research and Development Act, the report focuses on the infrastructure of the National Nanotechnology Initiative (NNI). The Committee on the Quadrennial Review...

On June 19 to June 20, 2025, the European Union (EU) Horizon Europe projects ACCORDs, iCare, MACRAMÉ, and nanoPASS are hosting a joint summit to address the needs of industry and regulators in assessing the safety and sustainability of advanced materials. The summit will feature discussions, latest method developments, and direct engagement with regulators, scientists, and industry professionals. Key sessions will focus on regulatory challenges, scientific developments, and pathways towards...

On April 8, 2025, the European Union (EU) Observatory for Nanomaterials (EUON) published a Nanopinion entitled “A Qualification System to Accelerate Development and Regulatory Implementation of New Approach Methodologies (NAMs)” by Andrea Haase, Ph.D., German Federal Institute for Risk Assessment (BfR), Shirin M. Usmani, Ph.D., BfR, Irene Cattaneo, European Food Safety Authority (EFSA), Maria Chiara Astuto, EFSA, and Francesco Cubadda, Ph.D., National Institute of Health (ISS). The authors...

On April 3, 2024, the European Commission’s (EC) Scientific Committee on Consumer Safety (SCCS) began a public consultation on its preliminary opinion on the safety of hydroxyapatite (nano) in oral products. The EC asked SCCS if it considers hydroxyapatite (nano) safe when used in toothpaste up to a maximum concentration of 29.5 percent and in mouthwash up to a maximum concentration of ten percent according to the specifications as reported in the submission, taking into account reasonably...

On February 6, 2025, the European Union (EU) Advocate General (EU AG) recommended that the European Court of Justice (ECJ) overturn the 2022 decision of the General Court annulling the 2019 harmonized classification and labeling of titanium dioxide as a carcinogenic substance by inhalation in certain powder forms. As reported in our December 6, 2022, memorandum, the court annulled the European Commission’s (EC) decision to classify titanium dioxide as a suspected human carcinogen. The French...

The Organisation for Economic Co-operation and Development (OECD) has published the Developments in Delegations on the Safety of Manufactured Nanomaterials and Advanced Materials between July 2023 and June 2024 -- Tour de Table (Tour de Table). Below are highlights on international developments from the Tour de Table: Canada continues with the risk assessments of zinc oxide and titanium dioxide at the nanoscale that are in commerce in Canada, to evaluate their potential for environmental and...

The Organisation for Economic Co-operation and Development (OECD) has published the Developments in Delegations on the Safety of Manufactured Nanomaterials and Advanced Materials between July 2023 and June 2024 -- Tour de Table (Tour de Table). The Tour de Table lists U.S. developments on the human health and environmental safety of nanomaterials. Risk assessment decisions, including the type of nanomaterials assessed, testing recommended, and outcomes of the assessment include: The U.S....

On December 19, 2024, the National Nanotechnology Coordination Office (NNCO) released The National Nanotechnology Initiative Supplement to the President’s 2025 Budget, which also serves as the annual report for the National Nanotechnology Initiative (NNI). According to the report, President Biden’s fiscal year (FY) 2025 budget requests over $2.2 billion for NNI, with cumulative funding totaling over $45 billion since the inception of NNI in 2001 when Congress approved increased funding for...

On December 18, 2024, the National Nanotechnology Initiative (NNI) announced the availability of the National Nanotechnology Initiative Environmental, Health, and Safety Research Strategy: 2024 Update. Prepared by the Nanotechnology Environmental and Health Implications (NEHI) Working Group within the Nanoscale Science, Engineering, and Technology (NSET) Subcommittee of the National Science and Technology Council, the 2024 update builds on the initial 2011 strategy, laying out a comprehensive,...

The European Union (EU) Observatory for Nanomaterials (EUON) announced on December 4, 2024, the availability of the European Chemical Agency’s (ECHA) Second interim evaluation of the European Union Observatory for Nanomaterials (EUON). Prepared by WSP acting as a third-party evaluator, the interim evaluation assesses EUON against six criteria: effectiveness; efficiency (including economy and proportionality); relevance; coherence; EU-added value; and utility. WSP’s recommendations include:...

On December 12, 2024, the U.S. Environmental Protection Agency (EPA) issued several final significant new use rules (SNUR) for certain chemical substances that were the subject of premanufacture notices (PMN) and are also subject to an Order issued by EPA pursuant to the Toxic Substances Control Act (TSCA). 89 Fed. Reg. 100361. Two of the SNURs are for substances identified generically as multi-walled carbon nanotubes (PMN P-21-216 and PMN P-21-217). The SNURs require persons who intend to...

The European Union (EU) Observatory for Nanomaterials (EUON) announced on November 12, 2024, that it published a new study evaluating nanomaterials applications in biocidal, plant protection, and fertilizing products used in agriculture. The study, “Collection and review of information on nanomaterial-based and nano-enabled plant protection products, biocidal products and fertilising products,” addresses knowledge gaps on applications, exposure, and hazards of nanomaterials and...

The European Commission’s (EC) Scientific Committee on Consumer Safety (SCCS) published its final opinion on a new coating for titanium dioxide on October 25, 2024. According to the abstract, SCCS concluded that “there are a number of uncertainties and data gaps that do not allow a conclusion on the safety of titanium dioxide (nano) coated with a combination of w/w 6% Aluminium Hydroxide, 14% Sodium Myristoyl Sarcosinate and 10% Dimethicone (Eclipse 70) -- either on the basis of a similarity...

The National Nanotechnology Coordination Office (NNCO) is organizing a series of National Nanotechnology Initiative (NNI) webinars on nanometrology, metrological challenges, and recent advances in three topical areas: food, agriculture, and the environment; nanoscale medical and pharmaceutical products; and nanoparticles in electronics. Registration is open for the sixth webinar in the series, “Nanometrology for Continuous and Automated Manufacturing.” The November 1, 2024, webinar will...

On October 10, 2024, the European Union (EU) Observatory for Nanomaterials (EUON) announced that, in collaboration with NovaMechanics, it is conducting a survey to gather insights on analytical methods for identifying, characterizing, and quantifying carbon-based nanomaterials in various matrices. According to EUON, the initiative “aims to assess the current situation about analytical methods for these types of nanomaterials, whether advanced or more classical nanomaterials.” Responses will...

The European Union (EU) Observatory for Nanomaterials (EUON) announced on September 26, 2024, that the European Food Safety Authority (EFSA) has published the following reports under its NAMs4NANO Project: “Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges” is a review article on the currently available New Approach Methodologies (NAM) that are potentially useful for risk assessment of nanoparticles in...

On October 5, 2024, the Minister of the Environment announced in the Canada Gazette publication of a proposed plan of priorities for the assessment of chemical substances. Under the 2023 amendments to the Canadian Environmental Protection Act, 1999 (CEPA), the Minister of the Environment and the Minister of Health are required to “develop, consult on and publish a plan with timelines” by June 2025. The proposed list of prioritized substances for assessment and the rationales for priorities...

On September 25, 2024, the National Institute for Occupational Safety and Health (NIOSH) posted a NIOSH Science Blog item entitled “Celebrating 20 Years of the Nanotechnology Research Center: Measuring the Small Things,” the final installment of the blog series commemorating the 20th anniversary of the Nanotechnology Research Center (NTRC). According to the item, when NTRC was created in 2004, one of its biggest challenges was understanding exactly what to measure and how to measure it....

The National Institute for Occupational Safety and Health (NIOSH) posted a blog item on September 10, 2024, entitled “NTRC Marks 20 Years of Studying Nanotoxicology: Highlights from the Toxicology and Internal Dose Team” that reviews the Nanotechnology Research Center’s (NTRC) achievements in the field of nanotechnology. The blog item highlights where NTRC started, where it is now, NTRC’s partnerships, and its work modeling workplace exposure to assess toxicity. According to the blog...

The National Nanotechnology Coordination Office (NNCO) is organizing a series of National Nanotechnology Initiative (NNI) webinars on nanometrology, metrological challenges, and recent advances in three topical areas: food, agriculture, and the environment; nanoscale medical and pharmaceutical products; and nanoparticles in electronics. Registration is open for the fifth webinar in the series, “Nanometrology for Continuous and Automated Manufacturing.” The October 4, 2024, webinar will...

As part of its quadrennial review of the National Nanotechnology Initiative (NNI), the National Academies of Sciences, Engineering, and Medicine (NASEM) will hold a virtual town hall on September 5, 2024, for stakeholders to share their thoughts on the future of nanotechnology in the United States. The overall objective of NASEM’s review is to identify opportunities and barriers to broadening access to nanotechnology research and development (R&D) infrastructure in the United States. As...

On August 20, 2024, the U.S. Environmental Protection Agency (EPA) proposed significant new use rules (SNUR) ) under the Toxic Substances Control Act (TSCA) for chemical substances, including graphene nanoplatelets (generic), that were the subject of premanufacture notices (PMN) and a Microbial Commercial Activity Notice (MCAN) and are also subject to a TSCA Order. 89 Fed. Reg. 67368. The SNURs would require persons who intend to manufacture (defined by statute to include import) or process any...

The U.S. Environmental Protection Agency (EPA) is seeking applications for research to develop and demonstrate nanosensor technology with the potential to detect, monitor, and degrade per- and polyfluoroalkyl substances (PFAS) in groundwater or surface water that may be used as drinking water sources. EPA states that advances in nanoscience and nanotechnology have the potential to address the challenges of detection and treatment of PFAS-contaminated waters. Because nanomaterials are smaller in...

The National Institute for Occupational Safety and Health (NIOSH) posted a blog item on August 1, 2024, entitled “When Nanoparticles Blow Up -- Explosion Hazards of Nanoparticles.” According to the blog item, little is known about the potential explosivity of any material when subdivided down to the nanoscale, prompting the NIOSH Nanotechnology Research Center (NTRC) to study the explosivity of several classes of nanoparticles: Nanocarbons: NIOSH screened single-walled carbon nanotubes,...

The 2024 National Institute for Occupational Safety and Health (NIOSH) Nanotechnology Research Center (NTRC) Nanotechnology Health and Safety Summit will be held October 9-10, 2024. During the conference, industry, academic, and government experts will share the latest advancements in occupational exposure to nanotechnology and advanced materials. The conference will also address critical safety and health challenges and offer valuable insights and foresights on a range of cutting-edge topics,...

The European Commission (EC) launched a call on July 5, 2024, for applications for members of the new Technology Council for Advanced Materials. According to the Directorate General (DG) for Internal Market, Industry, Entrepreneurship and SMEs, “this high-level group will coordinate efforts to meet future needs for advanced materials in Europe, and is key to building a single advanced materials ecosystem.” The EC’s February 2024 Communication on Advanced Materials for Industrial Leadership...

On July 1, 2024, the National Institute for Occupational Safety and Health (NIOSH) posted a NIOSH Science Blog item entitled “Celebrating 20 Years of the Nanotechnology Research Center: Highlights from Engineering Controls and Personal Protective Equipment,” part of a series commemorating the 20th anniversary of the Nanotechnology Research Center (NTRC). The item notes that NIOSH researchers “have conducted laboratory and field research to develop and implement science-based national...

The National Nanotechnology Initiative (NNI) and the National Nanotechnology Coordination Office (NNCO) are convening a July 24, 2024, workshop, “Responsible Development, Social Science, and the National Nanotechnology Initiative: A Workshop to Explore Past and Future Intersections.” According to NNI, the workshop will bring together federal experts in nanotechnology with social scientists with expertise on specific tools and frameworks relevant to the responsible development of emerging...

The European Chemicals Agency (ECHA) is evaluating the function of the European Union (EU) Observatory for Nanomaterials (EUON). As part of its evaluation, ECHA is conducting a survey to collect responses from EUON website visitors and stakeholders. The survey includes questions concerning evaluation criteria such as use, effectiveness, coherence, EU-added value, and utility. The survey notes that under an ongoing legislative proposal, the European Commission (EC) foresees setting up a common...

On June 12, 2024, the European Chemicals Agency (ECHA) announced that it updated its report on key areas of regulatory challenge, providing more detailed information on areas where scientific research is needed to protect human health and the environment from hazardous chemicals. The report addresses micro- and nano-size materials, stating: Why further research is needed: Critical test methods to address the human and environmental hazard and risk assessment of nanomaterials are still missing....